Drugs That Directly Target The Hepatitis C Virus - 94 Active Projects
 COMPANY DRUG Research Preclin Phase 1 Phase 2 Phase 3 NDA
Vertex
Telaprevir (VX-950) Protease Inhibitor
Phase 3
Vertex
VX-500 protease inhibitor Phase 1
Vertex

VX-813 2nd gen protease inhibitor
Pre Clinical
Schering

Boceprevir (SCH503034) Protease inhibitor
Phase 3
Intermune / Roche

Protease inhibitor ITMN-191 R7227
Phase 2
Intermune
2nd Gen. Protease inhibitor Pre Clinical
Roche / Pharmasset

R7128 nucleoside polymerase inhibitor
Phase 2
Roche / Medivir
HCV polymerase inhibitor
R & D
Medivir / Tibotec

TMC435 Protease inhibitor Phase 2
Medivir / Tibotec

polymerase inhibitor
R & D
Pfizer

PF-868554 Non-Nuc Polymerase inhibitor
Phase 2
Pfizer

PF-4878691
Phase 1
Benitec / Tacere Bio / Pfizer
RNA interference TT033
Pre Clinical
Boehringer Ingelheim
BI 201335 protease inhibitor
Phase 2
Boehringer Ingelheim

BI 207127 Polymerase inhib.
Phase 1
Intercell Novartis

IC41 Therapeutic Vacccine Phase 2
Chiron / CSL

Therapeutic Vaccine CSL123
Phase 2
Bristol-Myers Squibb
BMS-790052 NS5A Inhibitor
Phase 2
Bristol-Myers Squibb

BMS-791325 Protease inhibitor
Phase 1
Bristol-Myers Squibb

BMS-650032 NS3 Inhibitor
Phase 1
Bristol-Myers Squibb

BMS-824393
Phase 1
Merck

MK-7009 protease inhibitor
Phase 2
Sirna Therapeutics (aquired by Merck)
SIRNA-034 RNAi RNA interference
Pre Clinical
Isis / Merck

MK-0608 nucleoside polymerase inhib.
Phase 1
Anadys

ANA598 Polymerase inhib
Phase 2
ViroChem Pharma
(acquired by Vertex)
VCH-759 Non nuc Polymerase inhib
Phase 2
ViroChem Pharma
Polymerase inhib
Pre Clinical
ViroChem Pharma
Polymerase inhib
R & D
Globeimmune

GI 5005 Therapeutic Vaccine
Phase 2
iTherX
(formerly Immusol)
ITX5061 Entry Inhibitor Phase 2
iTherX
ITX4520 Entry Inhibitor
Pre Clinical
Idenix

IDX184 Nucleoside Polymerase Inhibitor
Phase 2
Idenix

Protease Inhibitors
IDX136&316
Pre Clinical
Idenix

Non-Nuc Polymerase Inhibitor
IDX375
Pre Clinical
Abbott

A-837093 Non-nuc polymerase inhib
Phase 1
Gilead

GS 9190 non-nuc polymerase inhibitor
Phase 1
Gilead / Achillion

ACH-1095 Protease inhibitor
Pre Clinical
Gilead

Protease
polymerase inhib
R & D
Presidio
PPI-461
NS5A inhibitor
Pre Clinical
Achillion

ACH-1625 Protease inhibitor
Phase 1
Aethlon Medical

Hemopurifier
Phase 1
Transgene

TG4040 (MVA-HCV) Therapeutic Vaccine
Phase 1
Tripep / Inovio

Therapeutic Vaccine Chronvac-C
Phase 1
Arrow Therapeutics (aquired by AstraZeneca)
A-831 NS5A inhibitor Phase 1
Arrow Therapeutics

A-689
NS5A Inhibitor
Pre Clinical
U of Mass. Med School

MBL-HCV1
human monoclonal antibody
Phase 1
Eiger BioPharmaceuticals
NS4B-RNA Binding Inhibitor
Phase 1
GENimmune (subsidiary of Innogenetics)
GNI-103 – Therapeutic vaccine
Pre Clinical
GENimmune

GNI-104 - monoclonal antibodie E1 protein
R & D
ChemDiv / IDialog
ID-12 small molecule Pre Clinical
Biocryst

Polymerase inhibitor
Pre Clinical
Genelabs GL59728 & GL60667

Non-nucleoside & nucleoside polymerase inhib.
Pre Clinical
Genelabs

NS5a NS4b & Replicase inhibitors R & D
ViRex Medical

Hepavaxx C Therapeutic Vaccine
Pre Clinical
GenPhar

Vaccine
Pre Clinical
Genmab

HuMax-HepC antibody
Pre Clinical
Abbott / Enanta

ABT-450 Protease inhib Phase 1
Pharmasset

PSI-7851 nucleoside polymerase inhib.
Phase 1
Inhibitex

INX08189 Polymerase inhibitor
Pre Clinical
Pharmasset

PSI-938 nucleoside polymerase inhib.
Pre Clinical
Enanta

Polymerase Inhibitor
Pre Clinical
Enanta

Cyclophilin binder
R & D
Dynavax

Immunostimulatory sequences
Type C TLR9 agonist
Pre Clinical
Protiva Biotherapeutics
siRNA
Pre Clinical
Phenomix

PHX1766 protease inhibitor Phase 1
Phenomix

protease inhibitor
R & D
Phenomix

Polymerase Inhibitor
R & D
Samaritan Pharmaceuticals

SP-30 entry inhibitor
Pre Clinical
Presidio (aquired from XTL )
NS5A inhibitors
Pre Clinical
Avila Therapeutics
AVL-181
protease inhibitor
Pre Clinical
Altor BioScience

Soluble T-cell Antigen Receptor
Pre Clinical
Arisyn Therapeutics

ATI-0810 (Formerly PG301029)
RNA and protein production inhibitor
Pre Clinical
Progenics

PRO 206
entry inhibitor
Pre Clinical
Migenix

N-nucleoside Poly inhib
R & D
Merck / Metabasis

Polymerase inhib
small molecule
R & D
PTC / Schering

IRES inhib
R & D
Vertex

Helicase inhibitor
R & D
Medivir / Roche

Polymerase inhibor R & D
Cetek

small molecule
R & D
Itherx (Immusol)/ Novartis

ITX2155 l
R & D
Argos Therapeutics

Therapeutic Vaccine R & D
Tibotec

Polymerase inhib. R & D
Regulus Therapeutics
(Alnylam
/ Isis)
microRNA antagonism of
miR-122 host gene
R & D
CombiMatrix

RNAi R & D
Arrow Therapeutics

Polymerase inhibitor
R & D
Boehringer Ingelheim / Biota
Nucleoside analogues
R & D
BioLeap

????
R & D
Alios BioPharma

Small Molecule Antivirals
R & D
Biotron

targeting HCV-p7
R & D
NanoViricides

HepaCide-I
R & D
Hanall

Antihepatitis agents
R & D
Astex Therapeutics

Enzyme Inhibitor R & D
Avexa / TargetDrug

replication inhib.
R & D
StemCells Inc

HCV resistant
Human liver engrafting cells
R & D
 Immune Modifiers and Other Non-specific Drugs - 40 Active Projects
 COMPANY DRUG Research Preclin Phase 1 Phase 2 Phase 3 NDA
Human Genome Sciences
Albuferon (interferon / albuminfusion)
Phase 3
SciClone Pharma / Sigmatau
Zadaxin - thymalfasin
Phase 3
SciClone Pharma

SCV-07
immunomodulator
Phase 2
Migenix

MX3235 Celgosivir alpha-glucosidase I inhibitor
Phase 2
Intarcia

Omega Interferon Phase 2
NABI

Polyclonal antibody
Civacir
Phase 2
Bioenvision

Suvus Phase 2
Transition Therapeutics
IET Interferon Enhancing Therapy
Phase 2
Romark Laboratories

Alinia Phase 2 Complete
Biolex / OctoPlus
Locteron controlled release interferon
Phase 2
Kemin Pharma

KPE02003002
Phase 2
VioQuest Pharmaceuticals

Lenocta (sodium stibogluconate
SSG)
Phase 2
Conatus

CTS-1027 MMP inhibitor
Phase 2
Jenkin

JKB-122 antiinflammatory
Phase 2
Oklahoma University
Health Sciences Center
Fluvastatin
Phase 2
Antipodean

Mito-Q antiinflammatory
Phase 2 Complete
Phynova
PYN17 antiviral anti-inflammatory anti-fibrotic
Phase 2
Canopus

CB5300 antiviral
Phase 2
Medtronic

continuous subcutaneous interferon
external pump infusion system
Phase 2
Phynova

PYN18 anti viral plant extract
Pre Clinical
Can-Fite
CF102 antiinflammatory
Phase 2
Biotron

BIT225 Phase 1
Peregrine Pharm

Bavituximab Phase 1
Enzo Biochem

Immune Regulator ECH18
Phase 1
Immunomedics

IMMU 105 Phase 1
Amarillo Bioscience / CytoPharm
Low Dose Oral Interferon Phase 1 Complete
Bristol-Myers Squibb (was owned by ZymoGenetics)
PEG-Interferon lambda Phase 1
Novelos

NOV-205 immunomodulating and antiinflammatory
Phase 1 Complete
Scynexis

SCY-635 Phase 1
Idera

IMO-2125 TLR9 Agonist
Phase 1
Anadys

ANA773 TLR7 agonist
Phase 1
Debiopharm

Debio 025 Cyclophilin Inhibitor
Phase 2
Medarex / Ono
MDX-1106 (ONO-4538) anti-PD1
Phase 1
Cytheris

CYT107
Interleukin-7
Phase 2
Cubist
CB-183872 Protein therapeutic - Formerly IB657 (Illumigen Biosciences)
Pre Clinical
Kemin Pharma

KPE00001133
Pre Clinical
REPLICor
REP 9C broad-spectrum entry inhibitor
Pre Clinical
Nautilus

Oral Belerofon
R & D
Anadys

AN 025-1
R & D
Genodyssee

GEA007.1 IFN alpha variant
Pre Clinical